Fig. 7
Effect of SPIO-clustering on cellular uptake behaviors of PEG-PLA polymeric micelles. (A) Mean fluorescence intensity of H1299 cells by flow cytometry (up). Fluorescence laser scanning microscopy of H1299 cells after 2 h of incubation (down). Doxo fluorescent images were acquired at λex = 485 nm, λem = 595 nm. (B) T2 relaxation rates (1/T2, sec− 1) of the collected H2009 cells after treatment with Doxo-SPIO-micelles. The inset shows T2 maps of cell samples. Data are expressed as mean ± stdev, ** p < 0.05, * p < 0.1