Fig. 5
Comparative efficacy study of the NC versus free drug combination (FDC) regimens in a preclinical human lung cancer mouse model. (A) Experimental schedule elucidating the establishment of the A549cisR xenograft model and drug administration. (B) The change in tumor volume was recorded using a Vernier caliper. Mice were treated with various drug combinations. (C) The tumor inhibition rate of each treatment is presented. (D) Variances in the bodyweight of each grouped mouse were measured after the treatment. (E-G) Histological assessment was used to evaluate the therapeutic effects. The excised tumors were harvested and histologically analyzed. Scale bars, 50 μm. (H and I) The quantification of TUNEL-positive (H) and Ki-67-positive (I) cells in each group is shown in the histogram