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Table 1 The difference between aptamers and antibodies

From: Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy

  Aptamers Antibodies
Size small (~ 12–30 kDa) relatively big (~ 150 – 170 kDa)
Target wide range immune related protein
Synthesis simple (chemically synthesis) complicate (in vivo production)
Stability stable susceptible to temperature and pH
Modification various modification limited modification
Storage term long relatively short
Cost low high
Immunogenicity low high