Table 1 The difference between aptamers and antibodies
From: Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
Aptamers | Antibodies | |
|---|---|---|
Size | small (~ 12–30 kDa) | relatively big (~ 150 – 170 kDa) |
Target | wide range | immune related protein |
Synthesis | simple (chemically synthesis) | complicate (in vivo production) |
Stability | stable | susceptible to temperature and pH |
Modification | various modification | limited modification |
Storage term | long | relatively short |
Cost | low | high |
Immunogenicity | low | high |