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Table 6 Average size of alginate microparticles prepared using droplet-based microfluidics with different gelation methods

From: Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Average size of microparticles Gelation method Reference
1–50 μm
10–300 nm
Internal gelation with water-soluble cross-linkers mixed with Na-alginate before droplet generation Rondeau and Cooper-White 2008a [39]
50–300 μm Internal gelation with water-soluble cross-linkers mixed with Na-alginate after droplet generation Xu et al. 2008 [54]
20–50 μm Liu et al. 2006 [28]
22–42 μm Trivedi et al. 2009 [48]
60–100 μm Internal gelation with water-insoluble cross-linkers mixed with Na-alginate after droplet generation Zhang et al. 2007 [61]
26 μm Akbari and Pirbodaghi 2014 [3]
50–100 μm Yu et al. 2019 [56]
10–50 μm Internal gelation with slightly water-soluble cross-linkers mixed with Na-alginate after droplet generation Utech et al. 2015 [49]
50–70 μm External gelation with on-chip introduction of cross-linkers Zhang et al. 2007 [61]
147–176 μm Liu et al. 2019 [29]
5–10 μm Pittermannová et al. 2016a [34]
6–10 μm Sugaya et al. 2011a [44]
100–200 μm External gelation with off-chip introduction of cross-linkers Hu et al. 2012 [20]
7–40 μm Zhang et al. 2020a [59]
  1. aPartially miscible fluids were used