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Table 2 Internal gelation with water-soluble cross-linkers: mixing cross-linkers with Na-alginate after droplet generation

From: Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Reference Xu et al., 2008 [54] Liu et al., 2006 [28] Trivedi et al., 2010 [47]
Droplet generation Concentration of Na-alginate 2 wt% 2 wt% 1 wt%
Continuous fluid octyl alcohol oil soybean oil silicone oil
Use of surfactant Not mentioned NO NO
Geometry Flow-focusing Flow-focusing Flow-focusing
Microfluidic material PMMA chip PDMS chip Fluoropolymer tubing
and junctions
Internal gelation by mixing Na-alginate and water-soluble cross-linker Cross-linkers CaCl2 (2 wt%) CaCl2 (2 wt%) BaCl2 (50 mM)
Geometry Cross-flowing Expansion chamber Cross-flowing
Mixing Coalescence of flows Coalescence of droplets Coalescence of droplets with flow