Table 1 Currently marketed pharmaceutical nanosuspension products
From: Emerging role of nanosuspensions in drug delivery systems
Trade name/Company | Drug | Dosage form/Route of administration | Nanosuspension method | Indication |
|---|---|---|---|---|
Abraxane®/Abraxia Biosciences | Paclitaxel | Freeze-dried powder for injection/ Parenteral | nab™ | Metastatic breast cancer |
Cesamet®/Lilly | Nabilone | Capsule/Oral | Coprecipitation | Antiemetic |
Emend®/Merck | Aprepiant | Capsule/Oral | Nanocrystal®Elan Nanosystems | Antiemetic |
Giris-PEG®/Novartis | Griseofulvin | Tablet/Oral | Coprecipittation | Antifungal |
Invega Sustenna®/ Johnson & Johnson | Palperidone palmitate | Liquid nanosuspension/ Parenteral | High pressure homogenization | Schizophrenia |
Megace ES®/Par Pharmaceutical Companies | Megestrol-acetate | Liquid nanosuspension/Oral | Nanocrystal®Elan Nanosystems Media milling | Anti-anorexic |
Rapammune®/Wyeth | Sirolimus | Tablet/Oral | Nanocrystal®Elan Nanosystems | Immunosuppressant |
Tricor®/Abbott | Fenofibrate | Tablet/Oral | Nanocrystal®Elan Nanosystems | Hypercholesterolemia |
Triglide®/First Horizon Pharma | Fenofibrate | Tablet/Oral | IDD-P® Skyepharma | Hypercholesterolemia |
Avinza®/King Pharmaceuticals | Morphine sulphate | Tablet/Oral | Nanocrystal®Elan Nanosystems | Psychostimulant |
Ritalin®/Novartis | Methyl Phenidate HCl | Tablet/Oral | Nanocrystal®Elan Nanosystems | Muscle Relaxant |
Zanaflex™/Acorda | Tizanidine HCl | Capsules/Oral | Nanocrystal®Elan Nanosystems | Muscle Relaxant |
Focalin®XR/Novartis | Dexmethylphenidate hydrochloride | Tablet/Oral | Nanocrystal®Elan Nanosystems | CNS Stimulant |
Ostim®/Heraseus Kulzer EquivaBone®/Zimmer Biomet OsSatura®/IsoTis Orthobiologics NanOss®/Rti Surgical | Hydroxyapatite | Paste/Injection | a | Bone substitute |
Vitoss®/Stryker | Calcium phosphate | Foam packs, Foam strips/Injection | a | Bone substitute |
Ryanodex®/Eagle Pharmaceuticals | Dantrolene sodium | Freeze-dried powder for injection/intravenous | a | Malignant hypothermia |