Optimization of silver nanoparticle synthesis by chemical reduction and evaluation of its antimicrobial and toxic activity

Quintero-Quiroz, Catalina; Acevedo, Natalia; Zapata-Giraldo, Jenniffer; Botero, Luz E.; Quintero, Julián; Zárate-Triviño, Diana; Saldarriaga, Jorge; Pérez, Vera Z.

doi:10.1186/s40824-019-0173-y

Table 1 Three-variable FCCCD design with four responses for the synthesis of AgNPs

From: Optimization of silver nanoparticle synthesis by chemical reduction and evaluation of its antimicrobial and toxic activity

Run	TSC(M)	AgNO₃	NaBH₄(M)	pH	Yield (UV-Vis area)	Size (nm)	PSGI(nm)	Polydispersity
1	0.05	0.05	0.01	10	7.98 ± 0.72	70.81 ± 8.90	55.61 ± 15.41	0.15
2	0.09	0.09	0.09	8	15.00 ± 1.37	17.66 ± 7.77	65.72 ± 13.30	0.64
3	0.05	0.05	0.05	8	8.55 ± 0.78	21.18 ± 7.35	99.40 ± 71.08	0.81
4	0.09	0.01	0.01	8	0.85 ± 0.08	159.60 ± 6.59	15.17 ± 4.78	0.31
5	0.05	0.05	0.05	12	7.87 ± 0.72	280.90 ± 27.47	461.60 ± 91.00	0.72
6	0.05	0.05	0.05	10	7.63 ± 0.69	13.66 ± 1.33	52.30 ± 6.72	0.55
7	0.05	0.05	0.09	10	8.10 ± 0.74	33.14 ± 3.24	99.99 ± 7.40	0.56
8	0.09	0.09	0.09	12	0.00 ± 0.00	8346.00 ± 816.00	8346.00 ± 816.00	1.00
9	0.05	0.05	0.05	10	7.97 ± 0.73	15.45 ± 1.51	66.73 ± 4.47	0.65
10	0.05	0.01	0.05	10	1.62 ± 0.15	372.60 ± 2.53	23.13 ± 4.08	0.55
11	0.01	0.09	0.01	8	2.83 ± 0.25	53.56 ± 9.14	46.28 ± 6.39	0.17
12	0.09	0.01	0.01	12	0.00 ± 0.00	3724.00 ± 364.20	3724.00 ± 364.20	1.00
13	0.09	0.05	0.05	10	7.82 ± 0.72	19.61 ± 1.91	87.18 ± 60.20	0.71
14	0.09	0.09	0.01	12	0.00 ± 0.00	3181.00 ± 311.10	3181.00 ± 311.10	1.00
15	0.05	0.05	0.05	10	8.02 ± 0.73	20.88 ± 2.04	96.12 ± 59.81	0.80
16	0.01	0.09	0.09	12	0.00 ± 0.00	37900.00 ± 3706.62	37900.00 ± 3706.62	0.23
17	0.05	0.05	0.05	10	7.76 ± 0.71	13.65 ± 1.33	59.91 ± 39.54	0.56
18	0.01	0.01	0.09	12	0.00 ± 0.00	30200.00 ± 2953.56	30200.00 ± 2953.56	0.28
19	0.09	0.01	0.09	8	1.37 ± 1.12	12.39 ± 1.21	36.56 ± 16.35	0.55
20	0.05	0.09	0.05	10	14.05 ± 1.28	15.96 ± 1.56	68.58 ± 48.06	0.62
21	0.01	0.01	0.09	8	1.13 ± 0.10	19.04 ± 1.86	68.14 ± 37.47	0.79
22	0.05	0.05	0.05	10	7.79 ± 0.71	26.95 ± 2.63	114.40 ± 76.30	0.89
23	0.09	0.01	0.09	12	0.94 ± 0.08	945.60 ± 92.47	741.50 ± 151.60	0.65
24	0.01	0.09	0.01	12	0.00 ± 0.00	985.80 ± 96.41	985.80 ± 18.03	0.90
25	0.09	0.09	0.01	8	3.29 ± 0.29	57.50 ± 5.62	125.00 ± 108.70	0.52
26	0.01	0.01	0.01	8	1.40 ± 0.13	40.87 ± 3.99	36.52 ± 15.27	0.11
27	0.01	0.05	0.05	10	7.42 ± 0.68	49.17 ± 4.80	101.6 ± 72.71	0.52
28	0.01	0.09	0.09	8	4.41 ± 0.40	45.59 ± 4.45	98.73 ± 65.20	0.51
29	0.01	0.01	0.01	12	0.02 ± 0.00	15.25 ± 1.49	62.07 ± 48.51	0.62

Values are expressed as mean ± standard deviation (n = 3). PSGI: peak size with greater intensity

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ISSN: 2055-7124

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