Fig. 5

M-T-D 3-in-1 typed IR-DBI: (a) Fluorescence imaging of NIR-irradiated IR-DBI and control indocyanine green (ICG), (b) Mitochondria-targeting activity of IR-DBI in 4T1 and MCF-7 cell lines, (c) NIR fluorescence imaging of IR-DBI in tumor cell lines (A549 and MCF-7 cells) and normal cells (HBE and MCF-10A cells), (d) NIR fluorescence imaging of IR-DBI in tumor cell (A549, QBC-939, HeLa, and 4T1 cells)-bearing mice, (e) PDT activity (i.e., singlet oxygen generation) of NIR-irradiated IR-DBI and ICG, (f) PTT activity (i.e., temperature elevation) of NIR-irradiated IR-DBI in 4T1 tumor-bearing mice, and (g) Tumor inhibition of NIR-irradiated IR-DBI in 4T1 tumor-bearing mice. Reproduced with permission from reference [29]; Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim