Table 1 Methods for incorporation of lipophilic drugs into chylomicrons

Postprandial state

(diet-derived)

Drugs are co-administered with food.

Chylomicrons are synthesized more than those of treating any other methods.

Uncontrollable method

[10] – [14]

Lipidic prodrugs

Drugs are covalently bound to a lipid moiety (fatty acid, glyceride, phospholipid).

Through covalent bonding with lipids, lipophilicity of drugs can be increased.

- Pharmaceutically inert

- Safety and toxicity problems

[12] – [15]

Lipid-based nanoparticles

(formulation-derived)

Administration of a single capsule of long-chain lipid can stimulate significant lymphatic transport of drugs.

- Solid lipid nanoparticles

- Self-nanoemulsifying drug delivery systems

- Emulsion

- Liposomes

- Effective carriers for drugs

- Stimulators of chylomicron production

The effect of the formulation on drug absorption and lymphatic transport is less clear.

[13] – [18]