Fig. 5
Biological safety of HCD matrix containing S-EGF and S-bFGF, in vivo. The matrix was applied on the wound of STZ-induced diabetic mice with following groups; defect control, HCD control, HCD + S-EGF 0.3 μg/cm2, HCD + S-EGF 1 μg/cm2, HCD + S-EGF 2.5 μg/cm2, HCD + S-bFGF 0.3 μg/cm2, HCD + S-bFGF 1 μg/cm2, and HCD + S-bFGF 2.5 μg/cm2. The macroscopic representative images were taken on day 0 and 7 (a) and quantitative analysis of wound area is measured (b). *p < 0.05, **p < 0.01