Articles

Sulfobetaine methacrylate hydrogel-coated anti-fouling surfaces for implantable biomedical devices

Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numero...

Authors: Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh and Ki Dong Park

The market trend analysis and prospects of cancer molecular diagnostics kits

The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnos...

Authors: Ju Hwan Seo, Joon Woo Lee and Daemyeong Cho

Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate

Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxi...

Authors: Jiyong Kim, Hwan D. Kim, Jungha Park, Eun-seo Lee, Eugene Kim, Seunghun S. Lee, Jin-Kyung Yang, Yoon-Sik Lee and Nathaniel S. Hwang

Comparison of in vivo antibacterial and antithrombotic activities of two types of pulmonary artery catheters in pig

During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications.

Authors: Jung Wook Han, Yeon Soo Shin, Jung Ju Kim and Ho Sung Son

Proangiogenic alginate-g-pyrrole hydrogel with decoupled control of mechanical rigidity and electrically conductivity

An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing...

Authors: Ross J. DeVolder, Yongbeom Seo and Hyunjoon Kong

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities

Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the s...

Authors: Sebastião van Uden, Joana Silva-Correia, Joaquim Miguel Oliveira and Rui Luís Reis

Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications

Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling act...

Authors: Trang Huyen Le Kim, Hwiseok Jun, Jin Ho Kim, Keunchil Park, Jee Seon Kim and Yoon Sung Nam

Oligochitosan-stabilized photoluminescent gold nanoconstructs for optical bioimaging

Gold nanoclusters (AuNCs) are typically composed of several to tens of gold atoms which are stabilized with biomacromolecules such as bovine serum albumin (BSA). Au NCs fluoresces in the visible to near infrar...

Authors: Donghyuck Yoo and Dongwon Lee

Effect of alginate concentration on chondrogenesis of co-cultured human adipose-derived stem cells and nasal chondrocytes: a biological study

The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogel...

Authors: Y. W. Ewa-Choy, B. Pingguan-Murphy, N. A. Abdul-Ghani, J. Jahendran and K. H. Chua

Functionalization of Ti-40Nb implant material with strontium by reactive sputtering

Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone...

Authors: Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming and Jürgen Janek

Polyion complex micelle formed from tetraphenylethene containing block copolymer

Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional funct...

Authors: Seong Min Lee and Woo-Dong Jang

Advances in medical adhesives inspired by aquatic organisms’ adhesion

In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dra...

Authors: Kyu Ha Park, Keum-Yong Seong, Seung Yun Yang and Sungbaek Seo

Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores

The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augme...

Authors: Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi and Sei Kwang Hahn

Modification and optimization of electrospun gelatin sheets by electron beam irradiation for soft tissue engineering

Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell mig...

Authors: Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park and Oh Hyeong Kwon

Anticancer activity of drug-loaded calcium phosphate nanocomposites against human osteosarcoma

Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticl...

Authors: Kyoung Dan Son and Young-Jin Kim

Silk fibroin/hydroxyapatite composite hydrogel induced by gamma-ray irradiation for bone tissue engineering

In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the ir...

Authors: Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon and Won Ho Park

Lamination of microfibrous PLGA fabric by electrospinning a layer of collagen-hydroxyapatite composite nanofibers for bone tissue engineering

To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen–hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coat...

Authors: Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung and Inn-Kyu Kang

In vitro ion adsorption and cytocompatibility of dicalcium phosphate ceramics

In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes...

Authors: Martha Schamel, Jake E. Barralet, Jürgen Groll and Uwe Gbureck

Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review

Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repa...

Authors: Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss and Michael Glogauer

In vivo analysis of covering materials composed of biodegradable polymers enriched with flax fibers

The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the su...

Authors: Tomasz Gredes, Sandra Schönitz, Tomasz Gedrange, Lukas Stepien, Karol Kozak and Christiane Kunert-Keil

Characterisation of a novel poly (ether ether ketone)/calcium sulphate composite for bone augmentation

Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the materi...

Authors: Erik A. B. Hughes and Liam M. Grover

Anti-aging effect and gene expression profiling of dung beetle glycosaminoglycan in aged rats

This study aimed to evaluate the anti-aging effect of a newly prepared insect-derived compound, dung beetle glycosaminoglycan (GAG), given intraperitoneally to old SD rats as part of their diet for 1 month. In...

Authors: Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jae Sam Hwang, Yi-Sook Jung and Kun-Koo Park

Calcium phosphates and silicon: exploring methods of incorporation

Bioinorganics have been explored as additives to ceramic bone graft substitutes with the aim to improve their performance in repair and regeneration of large bone defects. Silicon (Si), an essential trace elem...

Authors: Ana I. Rodrigues, Rui L. Reis, Clemens A. van Blitterswijk, Isabel B. Leonor and Pamela Habibović

Anti-apoptotic effect of dexamethasone in an ototoxicity model

Dexamethasone (DEX) is used for the treatment of various inner ear diseases. However, the molecular mechanism of DEX on gentamicin induced hair cell damage is not known. Therefore, this study investigated the ...

Authors: Jin Ho Lee, Se Heang Oh, Tae Ho Kim, Yoon Young Go and Jae-Jun Song

Erratum to: Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Authors: Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A. Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa and Heba Adel

Osteogenesis evaluation of duck’s feet-derived collagen/hydroxyapatite sponges immersed in dexamethasone

The aim of this study was to investigate the osteogenesis effects of DC and DC/HAp sponge immersed in without and with dexamethasone.

Authors: Yeon Ji Kook, Dae Hoon Lee, Jeong Eun Song, Nirmalya Tripathy, Yoo Shin Jeon, Ha Yan Jeon, Joaquim M. Oliveira, Rui L. Reis and Gilson Khang

Study of myoblast differentiation using multi-dimensional scaffolds consisting of nano and micropatterns

The topographical cue is major influence on skeletal muscle cell culture because the structure is highly organized and consists of long parallel bundles of multinucleated myotubes that are formed by differenti...

Authors: Sung Ho Cha, Hyun Jong Lee and Won-Gun Koh

Direct reprogramming and biomaterials for controlling cell fate

Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the pati...

Authors: Eunsol Kim and Giyoong Tae

Erratum to: Superior absorption and retention properties of foam-film silver dressing versus other commercially available silver dressing

Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam and Young-IL Jeong

Erratum to: Physical, morphological, and wound healing properties of a polyurethane foam-film dressing

Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller and Young-IL Jeong

Liposomal delivery systems for intestinal lymphatic drug transport

Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nan...

Authors: Hyeji Ahn and Ji-Ho Park

In-vitro toxicity study of poly(alkylphenol) as vulcanizing agent

In this study, cytotoxicity of various novel poly(alkylpehnol) derivatives which, one of constituent for vulcanizing agent, could be adjusted in medical elastic rubber applications were investigated under vari...

Authors: Joon Woo Chon, Ji Yun Lee, Yoon Ju Song, Jin Hwan Kim and Dong June Chung

MG-63 cells proliferation following various types of mechanical stimulation on cells by auxetic hybrid scaffolds

Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell.

Authors: Hong Jin Choi, Jun Jae Lee, Jung Bok Lee, Hak-Joon Sung, Jung-Woog Shin, Ji Won Shin, Yanru Wu and Jeong Koo Kim

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, an...

Authors: Rajendran JC Bose, Soo-Hong Lee and Hansoo Park

MG-63 osteoblast-like cell proliferation on auxetic PLGA scaffold with mechanical stimulation for bone tissue regeneration

Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation.

Authors: Hong Jin Choi, Jun Jae Lee, Yeong Jun Park, Jung-Woog Shin, Hak-Joon Sung, Ji Won Shin, Yanru Wu and Jeong Koo Kim

A comparative study of enzyme initiators for crosslinking phenol-functionalized hydrogels for cell encapsulation

Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same...

Authors: Justine J. Roberts, Pratibha Naudiyal, Khoon S. Lim, Laura A. Poole-Warren and Penny J. Martens

Polypyrrole-incorporated conductive hyaluronic acid hydrogels

Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not elec...

Authors: Jongcheol Yang, Goeun Choe, Sumi Yang, Hyerim Jo and Jae Young Lee

A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection

Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low cytotoxicity. However, CPPs have reported to h...

Authors: Chanuk Jeong, Jisang Yoo, DaeYong Lee and Yeu-Chun Kim

Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers

Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA micr...

Authors: Cheolbyong Chun, Deuk Yong Lee, Jin-Tae Kim, Mi-Kyung Kwon, Young-Zu Kim and Seok-Soon Kim

Erratum to: Direct photo-patterning on anthracene containing polymer for guiding stem cell adhesion

Authors: Jungmok You, June Seok Heo, Hyun Ok Kim and Eunkyoung Kim

Solid organ fabrication: comparison of decellularization to 3D bioprinting

Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution i...

Authors: Jangwook P. Jung, Didarul B. Bhuiyan and Brenda M. Ogle

Superior absorption and retention properties of foam-film silver dressing versus other commercially available silver dressing

The aim of this study is to investigate the physicochemical and structural properties of Medifoam®Silver and to compare with other commercially available silver-containing polyurethane (PU) foam dressing in vi...

Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam and Young-IL Jeong

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage ...

Authors: Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A. Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa and Heba Adel

Direct photo-patterning on anthracene containing polymer for guiding stem cell adhesion

Various micropatterned surfaces capable of guiding the selective adhesion of biomolecules such as proteins and cells are of great interests in biosensor, diagnostics, drug screening, and tissue engineering. In...

Authors: Jungmok You, June Seok Heo, Hyun Ok Kim and Eunkyoung Kim

Study on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices

Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitm...

Authors: Dayoung Yoon, Hyerim Kim, Eojin Lee, Min Hee Park, Seok Chung, Hojeong Jeon, Cheol-Hee Ahn and Kangwon Lee

Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction

After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared...

Authors: Chang-Shik Kim, Kyung-Hye Jung, Hun Kim, Chan-Bong Kim and Inn-Kyu Kang

Cellulose membrane as a biomaterial: from hydrolysis to depolymerization with electron beam

The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its...

Authors: Mi Young Eo, Huan Fan, Yun Ju Cho, Soung Min Kim and Suk Keun Lee

Antibacterial potency of different deposition methods of silver and copper containing diamond-like carbon coated polyethylene

Antibacterial coatings of medical devices have been introduced as a promising approach to reduce the risk of infection. In this context, diamond-like carbon coated polyethylene (DLC-PE) can be enriched with ba...

Authors: Norbert Harrasser, Sebastian Jüssen, Andreas Obermeir, Ralf Kmeth, Bernd Stritzker, Hans Gollwitzer and Rainer Burgkart

Engineering approaches for regeneration of T lymphopoiesis

T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique org...

Authors: Kyung-Ho Roh and Krishnendu Roy

Multiple genetically engineered humanized microenvironments in a single mouse

Immunodeficient mouse models that accept human cell and tissue grafts can contribute greater knowledge to human stem cell research. In this technical report, we used biomaterial implants seeded with geneticall...

Authors: Jungwoo Lee, Dirk Heckl and Biju Parekkadan