Articles

MG-63 cells proliferation following various types of mechanical stimulation on cells by auxetic hybrid scaffolds

Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell.

Authors: Hong Jin Choi, Jun Jae Lee, Jung Bok Lee, Hak-Joon Sung, Jung-Woog Shin, Ji Won Shin, Yanru Wu and Jeong Koo Kim

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, an...

Authors: Rajendran JC Bose, Soo-Hong Lee and Hansoo Park

MG-63 osteoblast-like cell proliferation on auxetic PLGA scaffold with mechanical stimulation for bone tissue regeneration

Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation.

Authors: Hong Jin Choi, Jun Jae Lee, Yeong Jun Park, Jung-Woog Shin, Hak-Joon Sung, Ji Won Shin, Yanru Wu and Jeong Koo Kim

A comparative study of enzyme initiators for crosslinking phenol-functionalized hydrogels for cell encapsulation

Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same...

Authors: Justine J. Roberts, Pratibha Naudiyal, Khoon S. Lim, Laura A. Poole-Warren and Penny J. Martens

Polypyrrole-incorporated conductive hyaluronic acid hydrogels

Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not elec...

Authors: Jongcheol Yang, Goeun Choe, Sumi Yang, Hyerim Jo and Jae Young Lee

A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection

Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low cytotoxicity. However, CPPs have reported to h...

Authors: Chanuk Jeong, Jisang Yoo, DaeYong Lee and Yeu-Chun Kim

Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers

Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA micr...

Authors: Cheolbyong Chun, Deuk Yong Lee, Jin-Tae Kim, Mi-Kyung Kwon, Young-Zu Kim and Seok-Soon Kim

Erratum to: Direct photo-patterning on anthracene containing polymer for guiding stem cell adhesion

Authors: Jungmok You, June Seok Heo, Hyun Ok Kim and Eunkyoung Kim

Solid organ fabrication: comparison of decellularization to 3D bioprinting

Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution i...

Authors: Jangwook P. Jung, Didarul B. Bhuiyan and Brenda M. Ogle

Superior absorption and retention properties of foam-film silver dressing versus other commercially available silver dressing

The aim of this study is to investigate the physicochemical and structural properties of Medifoam®Silver and to compare with other commercially available silver-containing polyurethane (PU) foam dressing in vi...

Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam and Young-IL Jeong

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage ...

Authors: Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A. Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa and Heba Adel

Direct photo-patterning on anthracene containing polymer for guiding stem cell adhesion

Various micropatterned surfaces capable of guiding the selective adhesion of biomolecules such as proteins and cells are of great interests in biosensor, diagnostics, drug screening, and tissue engineering. In...

Authors: Jungmok You, June Seok Heo, Hyun Ok Kim and Eunkyoung Kim

Study on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices

Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitm...

Authors: Dayoung Yoon, Hyerim Kim, Eojin Lee, Min Hee Park, Seok Chung, Hojeong Jeon, Cheol-Hee Ahn and Kangwon Lee

Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction

After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared...

Authors: Chang-Shik Kim, Kyung-Hye Jung, Hun Kim, Chan-Bong Kim and Inn-Kyu Kang

Cellulose membrane as a biomaterial: from hydrolysis to depolymerization with electron beam

The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its...

Authors: Mi Young Eo, Huan Fan, Yun Ju Cho, Soung Min Kim and Suk Keun Lee

Antibacterial potency of different deposition methods of silver and copper containing diamond-like carbon coated polyethylene

Antibacterial coatings of medical devices have been introduced as a promising approach to reduce the risk of infection. In this context, diamond-like carbon coated polyethylene (DLC-PE) can be enriched with ba...

Authors: Norbert Harrasser, Sebastian Jüssen, Andreas Obermeir, Ralf Kmeth, Bernd Stritzker, Hans Gollwitzer and Rainer Burgkart

Engineering approaches for regeneration of T lymphopoiesis

T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique org...

Authors: Kyung-Ho Roh and Krishnendu Roy

Multiple genetically engineered humanized microenvironments in a single mouse

Immunodeficient mouse models that accept human cell and tissue grafts can contribute greater knowledge to human stem cell research. In this technical report, we used biomaterial implants seeded with geneticall...

Authors: Jungwoo Lee, Dirk Heckl and Biju Parekkadan

Bio-inspired strategies for designing antifouling biomaterials

Contamination of biomedical devices in a biological medium, biofouling, is a major cause of infection and is entirely avoidable. This mini-review will coherently present the broad range of antifouling strategi...

Authors: Vinod B. Damodaran and N. Sanjeeva Murthy

Physical, morphological, and wound healing properties of a polyurethane foam-film dressing

We investigated the physicochemical properties of Medifoam® N and its wound healing performance compared to other commercially available polyurethane (PU) foam dressing in vitro and in vivo to gain insight in ...

Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller and Young-IL Jeong

Biomimetic microenvironments for regenerative endodontics

Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem ce...

Authors: Sagar N. Kaushik, Bogeun Kim, Alexander M. Cruz Walma, Sung Chul Choi, Hui Wu, Jeremy J. Mao, Ho-Wook Jun and Kyounga Cheon

Antifibrotic therapies to control cardiac fibrosis

Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis continuously expa...

Authors: Zhaobo Fan and Jianjun Guan

Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone

This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic me...

Authors: Cen Chen, Sumi Bang, Younghak Cho, Sahnghoon Lee, Inseop Lee, ShengMin Zhang and Insup Noh

Biomimetic substrate control of cellular mechanotransduction

Extracellular mechanophysical signals from both static substrate cue and dynamic mechanical loading have strong potential to regulate cell functions. Most of the studies have adopted either static or dynamic c...

Authors: Mohammad Nahid Andalib, Yuris Dzenis, Henry J. Donahue and Jung Yul Lim

3-dimensional bioprinting for tissue engineering applications

The 3-dimensional (3D) printing technologies, referred to as additive manufacturing (AM) or rapid prototyping (RP), have acquired reputation over the past few years for art, architectural modeling, lightweight...

Authors: Bon Kang Gu, Dong Jin Choi, Sang Jun Park, Min Sup Kim, Chang Mo Kang and Chun-Ho Kim

Polymer mesh scaffold combined with cell-derived ECM for osteogenesis of human mesenchymal stem cells

Tissue-engineered scaffold should mimic the structure and biological function of the extracellular matrix and have mechanically supportive properties for tissue regeneration. In this study, we utilized a PLGA/...

Authors: Yong Kwan Noh, Ping Du, In Gul Kim, Jaehoon Ko, Seong Who Kim and Kwideok Park

Development of Stabilized Growth Factor-Loaded Hyaluronate– Collagen Dressing (HCD) matrix for impaired wound healing

Diabetes mellitus is a disease lack of insulin, which has severely delayed and impaired wound healing capacity. In the previous studies, various types of scaffolds and growth factors were used in impaired woun...

Authors: Seong Mi Choi, Hyun Aae Ryu, Kyoung-Mi Lee, Hyun Jung Kim, Ik Kyu Park, Wan Jin Cho, Hang-Cheol Shin, Woo Jin Choi and Jin Woo Lee

Research trends in biomimetic medical materials for tissue engineering: commentary

We introduce our active experts’ communications and reviews (Part II) of 2015 Korea-China Joint Symposium on Biomimetic Medical Materials in Republic of Korea, which reflect their perspectives on current resea...

Authors: Ki Dong Park, Xiumei Wang, Jae Young Lee, Kyung Min Park, ShengMin Zhang and Insup Noh

Effects of poly(L-lactide-ε-caprolactone) and magnesium hydroxide additives on physico-mechanical properties and degradation of poly(L-lactic acid)

Biodegradable poly(L-lactic acid) (PLLA) is one of the most widely used polymer in biomedical devices, but it still has limitations such as inherent brittleness and acidic degradation products. In this work, P...

Authors: Eun Young Kang, Eugene Lih, Ik Hwan Kim, Yoon Ki Joung and Dong Keun Han

Erratum to: Investigation of the changes of biophysical/mechanical characteristics of differentiating preosteoblasts in vitro

Authors: Ramesh Subbiah, Muhammad Suhaeri, Mintai Peter Hwang, Woojun Kim and Kwideok Park

Light enhanced bone regeneration in an athymic nude mouse implanted with mesenchymal stem cells embedded in PLGA microspheres

Biodegradable microspheres fabricated from poly (Lactic-co-glycolic acid) (PLGA) have attracted considerable attention in the bone tissue regeneration field. In this study, rabbit mesenchymal stem cells (rMSCs...

Authors: Ji Sun Park and Keun-Hong Park

Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

In order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we pre...

Authors: Gyeong-Hyeon Gwak, Ae-Jin Choi, Yeoung-Seuk Bae, Hyun-Jin Choi and Jae-Min Oh

Multiphoton imaging of myogenic differentiation in gelatin-based hydrogels as tissue engineering scaffolds

Hydrogels can serve as three-dimensional (3D) scaffolds for cell culture and be readily injected into the body. Recent advances in the image technology for 3D scaffolds like hydrogels have attracted considerab...

Authors: Min Jeong Kim, Yong Cheol Shin, Jong Ho Lee, Seung Won Jun, Chang-Seok Kim, Yunki Lee, Jong-Chul Park, Soo-Hong Lee, Ki Dong Park and Dong-Wook Han

Effects of Collagen Grafting on Cell Behaviors in BCP Scaffold with Interconnected Pore Structure

This study was to investigate the effect of collagen grafted porous biphasic calcium phosphate (BCP) on cell attachment, proliferation, and differentiation. Porous BCP scaffolds with interconnected micropore s...

Authors: Dong-Jun Yang, Jae-Hui Jeon, Sun-Young Lee, Hyun-Wook An, Keun Oh Park, Kwang-Bum Park and Sukyoung Kim

Long and short range order structural analysis of In-situ formed biphasic calcium phosphates

Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-si...

Authors: Dong-Hyun Kim, Kyu-Hong Hwang, Ju Dong Lee, Hong-Chae Park and Seog-Young Yoon

The metallurgical characteristics of non-precious alloys using Nd:YAG laser welding

This study aimed to determine the effect of hardness change according to penetration depth in the laser fusing zone and observed the correlation of the microstructure as an Nd:YAG laser was irradiated to Ni-Cr...

Authors: Jun-Hee Lee, Seok-Kyu Choi and Min-Ho Hong

Investigation of the changes of biophysical/mechanical characteristics of differentiating preosteoblasts in vitro

Topography, stiffness, and composition of biomaterials play a crucial role in cell behaviors. In this study, we have investigated biochemical (gene markers), biophysical (roughness), and biomechanical (stiffne...

Authors: Ramesh Subbiah, Muhammad Suhaeri, Mintai Peter Hwang, Woojun Kim and Kwideok Park

Effect of topographical control by a micro-molding process on the activity of human Mesenchymal Stem Cells on alumina ceramics

Numerous studies have reported that microgrooves on metal and polymer materials can affect cell adhesion, proliferation, differentiation and guidance. However, our knowledge of the cell activity associated wit...

Authors: Soo-Yean Kim, Jong-Ho Kang, Won-Seon Seo, Suk-Won Lee, Nam-Sik Oh, Hyung-Koun Cho and Myung-Hyun Lee

Haemostatic chitosan coated gauze: in vitro interaction with human blood and in-vivo effectiveness

Chitosan and its derivates are widely used for biomedical application due to antioxidative, anti-inflammatory, antimicrobial and tissue repair induced properties. Chitosan-based materials also used as a haemos...

Authors: M. Pogorielov, O. Kalinkevich, V. Deineka, V. Garbuzova, A. Solodovnik, A. Kalinkevich, T. Kalinichenko, A. Gapchenko, A. Sklyar and S. Danilchenko

Encapsulation of pancreatic islet with HMGB1 fragment for attenuating inflammation

Pancreatic islet encapsulation is one way to address the disadvantages of islet transplantation. Not only does encapsulation involve bidirectional diffusion of nutrients, oxygen, and glucose, but also it prote...

Authors: Eun Hee Jo, Yong Hwa Hwang and Dong Yun Lee

Preparation and investigation of hydrolyzed polyacrylonitrile as a preliminary biomedical hydrogel

Hydrolyzed polyacrylonitrile (HPAN) has attracted much attention as a hydrogel for a broad range of biomedical applications. Therefore, in this study, we prepared HPAN derivatives with controllable compositions b...

Authors: Ji Hoon Park, Guo Zhe Tai, Bo Keun Lee, Seung Hun Park, Ja Yong Jang, Jung Soo Lee, Jae Ho Kim, Kwideok Park, Ju Woong Jang and Moon Suk Kim

Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants

The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer ...

Authors: Fredrik Ejserholm, John Stegmayr, Patrik Bauer, Fredrik Johansson, Lars Wallman, Martin Bengtsson and Stina Oredsson

Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration

Angiogenin (ANG) is a potent stimulator of angiogenesis. The aim of this study was to fabricate an ANG-loaded scaffold and to evaluate its angiogenic and osteogenic effects. In this study, we fabricated an ANG...

Authors: Beom-Su Kim, Jin-Seong Kim, Sun-Sik Yang, Hyung-Woo Kim, Hun Jun Lim and Jun Lee

Guided bone regeneration using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked type-I collagen membrane with biphasic calcium phosphate at rabbit calvarial defects

In-vitro and animal studies using EDC cross-linked membranes have shown great resistance to enzymatic digestion as well as low cytotoxicity, and indicated its potential expediency as a barrier ...

Authors: Jin-Young Park, Im-Hee Jung, You-Kyoung Kim, Hyun-Chang Lim, Jung-Seok Lee, Ui-Won Jung and Seong-Ho Choi

Rapid bone regeneration by Escherichia coli-derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model

The aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diamete...

Authors: Chung-Hoon Chung, You-Kyoung Kim, Jung-Seok Lee, Ui-Won Jung, Eun-Kyoung Pang and Seong-Ho Choi

Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion

Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, thes...

Authors: Won-Young Choi, Hyoun-Ee Kim, Young-Wook Moon, Kwan-Ha Shin and Young-Hag Koh

Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on Enterococcus faecalis and Treponema denticola

A triple antibiotic mixture (ciprofloxacin; CF, metronidazole; MN, and minocycline; MC) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical roo...

Authors: Sagar N Kaushik, Jessica Scoffield, Adinarayana Andukuri, Grant C Alexander, Taneidra Walker, Seokgon Kim, Sung Chul Choi, Brigitta C Brott, Paul D Eleazer, Jin-Yong Lee, Hui Wu, Noel K Childers, Ho-Wook Jun, Jae-Hong Park and Kyounga Cheon

Performance of universal adhesives on bonding to leucite-reinforced ceramic

This study aimed to investigate the microshear bond strength of universal bonding adhesives to leucite-reinforced glass-ceramic.

Authors: Ryan Jin-Young Kim, Jung-Soo Woo, In-Bog Lee, Young-Ah Yi, Ji-Yun Hwang and Deog-Gyu Seo

Titanium surface modification by using microwave-induced argon plasma in various conditions to enhance osteoblast biocompatibility

Titanium is a well proven implantable material especially for osseointegratable implants by its biocompatibility and anti-corrosive surface properties. Surface characteristics of the implant play an important ...

Authors: Gyeung Mi Seon, Hyok Jin Seo, Soon Young Kwon, Mi Hee Lee, Byeong-Ju Kwon, Min Sung Kim, Min-Ah Koo, Bong Joo Park and Jong-Chul Park

Synthesis and in vitro characterizations of porous carboxymethyl cellulose-poly(ethylene oxide) hydrogel film

Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Por...

Authors: Su Yeon Lee, Sumi Bang, Sumi Kim, Seong Yeon Jo, Bum-Chul Kim, Yunjae Hwang and Insup Noh