Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem ce...
Authors: Sagar N. Kaushik, Bogeun Kim, Alexander M. Cruz Walma, Sung Chul Choi, Hui Wu, Jeremy J. Mao, Ho-Wook Jun and Kyounga Cheon
Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis continuously expa...
This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic me...
Extracellular mechanophysical signals from both static substrate cue and dynamic mechanical loading have strong potential to regulate cell functions. Most of the studies have adopted either static or dynamic c...
Authors: Mohammad Nahid Andalib, Yuris Dzenis, Henry J. Donahue and Jung Yul Lim
The 3-dimensional (3D) printing technologies, referred to as additive manufacturing (AM) or rapid prototyping (RP), have acquired reputation over the past few years for art, architectural modeling, lightweight...
Authors: Bon Kang Gu, Dong Jin Choi, Sang Jun Park, Min Sup Kim, Chang Mo Kang and Chun-Ho Kim
Tissue-engineered scaffold should mimic the structure and biological function of the extracellular matrix and have mechanically supportive properties for tissue regeneration. In this study, we utilized a PLGA/...
Authors: Yong Kwan Noh, Ping Du, In Gul Kim, Jaehoon Ko, Seong Who Kim and Kwideok Park
Diabetes mellitus is a disease lack of insulin, which has severely delayed and impaired wound healing capacity. In the previous studies, various types of scaffolds and growth factors were used in impaired woun...
Authors: Seong Mi Choi, Hyun Aae Ryu, Kyoung-Mi Lee, Hyun Jung Kim, Ik Kyu Park, Wan Jin Cho, Hang-Cheol Shin, Woo Jin Choi and Jin Woo Lee
We introduce our active experts’ communications and reviews (Part II) of 2015 Korea-China Joint Symposium on Biomimetic Medical Materials in Republic of Korea, which reflect their perspectives on current resea...
Authors: Ki Dong Park, Xiumei Wang, Jae Young Lee, Kyung Min Park, ShengMin Zhang and Insup Noh
Biodegradable poly(L-lactic acid) (PLLA) is one of the most widely used polymer in biomedical devices, but it still has limitations such as inherent brittleness and acidic degradation products. In this work, P...
Authors: Eun Young Kang, Eugene Lih, Ik Hwan Kim, Yoon Ki Joung and Dong Keun Han
Biodegradable microspheres fabricated from poly (Lactic-co-glycolic acid) (PLGA) have attracted considerable attention in the bone tissue regeneration field. In this study, rabbit mesenchymal stem cells (rMSCs...
In order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we pre...
Hydrogels can serve as three-dimensional (3D) scaffolds for cell culture and be readily injected into the body. Recent advances in the image technology for 3D scaffolds like hydrogels have attracted considerab...
Authors: Min Jeong Kim, Yong Cheol Shin, Jong Ho Lee, Seung Won Jun, Chang-Seok Kim, Yunki Lee, Jong-Chul Park, Soo-Hong Lee, Ki Dong Park and Dong-Wook Han
This study was to investigate the effect of collagen grafted porous biphasic calcium phosphate (BCP) on cell attachment, proliferation, and differentiation. Porous BCP scaffolds with interconnected micropore s...
Authors: Dong-Jun Yang, Jae-Hui Jeon, Sun-Young Lee, Hyun-Wook An, Keun Oh Park, Kwang-Bum Park and Sukyoung Kim
Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-si...
Authors: Dong-Hyun Kim, Kyu-Hong Hwang, Ju Dong Lee, Hong-Chae Park and Seog-Young Yoon
This study aimed to determine the effect of hardness change according to penetration depth in the laser fusing zone and observed the correlation of the microstructure as an Nd:YAG laser was irradiated to Ni-Cr...
Authors: Jun-Hee Lee, Seok-Kyu Choi and Min-Ho Hong
Topography, stiffness, and composition of biomaterials play a crucial role in cell behaviors. In this study, we have investigated biochemical (gene markers), biophysical (roughness), and biomechanical (stiffne...
Authors: Ramesh Subbiah, Muhammad Suhaeri, Mintai Peter Hwang, Woojun Kim and Kwideok Park
Numerous studies have reported that microgrooves on metal and polymer materials can affect cell adhesion, proliferation, differentiation and guidance. However, our knowledge of the cell activity associated wit...
Authors: Soo-Yean Kim, Jong-Ho Kang, Won-Seon Seo, Suk-Won Lee, Nam-Sik Oh, Hyung-Koun Cho and Myung-Hyun Lee
Chitosan and its derivates are widely used for biomedical application due to antioxidative, anti-inflammatory, antimicrobial and tissue repair induced properties. Chitosan-based materials also used as a haemos...
Authors: M. Pogorielov, O. Kalinkevich, V. Deineka, V. Garbuzova, A. Solodovnik, A. Kalinkevich, T. Kalinichenko, A. Gapchenko, A. Sklyar and S. Danilchenko
Pancreatic islet encapsulation is one way to address the disadvantages of islet transplantation. Not only does encapsulation involve bidirectional diffusion of nutrients, oxygen, and glucose, but also it prote...
Authors: Eun Hee Jo, Yong Hwa Hwang and Dong Yun Lee
Hydrolyzed polyacrylonitrile (HPAN) has attracted much attention as a hydrogel for a broad range of biomedical applications. Therefore, in this study, we prepared HPAN derivatives with controllable compositions b...
Authors: Ji Hoon Park, Guo Zhe Tai, Bo Keun Lee, Seung Hun Park, Ja Yong Jang, Jung Soo Lee, Jae Ho Kim, Kwideok Park, Ju Woong Jang and Moon Suk Kim
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer ...
Authors: Fredrik Ejserholm, John Stegmayr, Patrik Bauer, Fredrik Johansson, Lars Wallman, Martin Bengtsson and Stina Oredsson
Angiogenin (ANG) is a potent stimulator of angiogenesis. The aim of this study was to fabricate an ANG-loaded scaffold and to evaluate its angiogenic and osteogenic effects. In this study, we fabricated an ANG...
Authors: Beom-Su Kim, Jin-Seong Kim, Sun-Sik Yang, Hyung-Woo Kim, Hun Jun Lim and Jun Lee
In-vitro and animal studies using EDC cross-linked membranes have shown great resistance to enzymatic digestion as well as low cytotoxicity, and indicated its potential expediency as a barrier ...
Authors: Jin-Young Park, Im-Hee Jung, You-Kyoung Kim, Hyun-Chang Lim, Jung-Seok Lee, Ui-Won Jung and Seong-Ho Choi
The aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diamete...
Authors: Chung-Hoon Chung, You-Kyoung Kim, Jung-Seok Lee, Ui-Won Jung, Eun-Kyoung Pang and Seong-Ho Choi
Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, thes...
Authors: Won-Young Choi, Hyoun-Ee Kim, Young-Wook Moon, Kwan-Ha Shin and Young-Hag Koh
A triple antibiotic mixture (ciprofloxacin; CF, metronidazole; MN, and minocycline; MC) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical roo...
Authors: Sagar N Kaushik, Jessica Scoffield, Adinarayana Andukuri, Grant C Alexander, Taneidra Walker, Seokgon Kim, Sung Chul Choi, Brigitta C Brott, Paul D Eleazer, Jin-Yong Lee, Hui Wu, Noel K Childers, Ho-Wook Jun, Jae-Hong Park and Kyounga Cheon
Titanium is a well proven implantable material especially for osseointegratable implants by its biocompatibility and anti-corrosive surface properties. Surface characteristics of the implant play an important ...
Authors: Gyeung Mi Seon, Hyok Jin Seo, Soon Young Kwon, Mi Hee Lee, Byeong-Ju Kwon, Min Sung Kim, Min-Ah Koo, Bong Joo Park and Jong-Chul Park
Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Por...
Authors: Su Yeon Lee, Sumi Bang, Sumi Kim, Seong Yeon Jo, Bum-Chul Kim, Yunjae Hwang and Insup Noh
To develop biocompatible bony regeneration materials, allogenic, xenogenic and synthetic bones have been irradiated by an electron beam to change the basic structures of their inorganic materials. The optimal ...
Authors: Soung Min Kim, Huan Fan, Yun Ju Cho, Mi Young Eo, Ji Hyun Park, Byung Nam Kim, Byung Cheol Lee and Suk Keun Lee
Dental resin monomers that are leached from the resin matrix due to incomplete polymerization can affect the viability and various functions of oral tissues and cells. In this study, the effects of triethylene...
Authors: Ji Hyun Kwon, Hee Chul Park, Tingting Zhu and Hyeong-Cheol Yang
The aim of this study was to characterize the efficacy of nano-hydroxyapatite-coated silk fibroin constructs as a scaffold for bone tissue engineering and to determine the osteogenic effect of human dental pul...
Authors: Jin-Young Park, Cheryl Yang, Im-Hee Jung, Hyun-Chang Lim, Jung-Seok Lee, Ui-Won Jung, Young-Kwon Seo, Jung-Keug Park and Seong-Ho Choi
Recently, postnatal stem cells from dental papilla with neural crest origin have been considered as one of potent stem cell sources in regenerative medicine regarding their multi-differentiation capacity and r...
Authors: Byung-Chul Kim, So Yeon Kim, Yong-Dae Kwon, Sung Chul Choe, Dong-Wook Han and Yu-Shik Hwang
Nucleic acid vaccines have attracted many attentions since they have presented some superiority over traditional vaccines. However, they could only induce moderate immunogenicity. The route and formulation of ...
Authors: Jun Yang, Yan Li, Shubin Jin, Jing Xu, Paul C Wang, Xing-Jie Liang and Xin Zhang
The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 ...
Authors: Eun-Ung Lee, Dong-Ju Kim, Hyun-Chang Lim, Jung-Seok Lee, Ui-Won Jung and Seong-Ho Choi
Regulating stem cell microenvironment is one of the essential elements in stem cell culture. Recently, carbon nanotube (CNT) has come into the spotlight as a biomaterial that retains unique properties. Based o...
Authors: Ju-Ro Lee, Seungmi Ryu, Soojin Kim and Byung-Soo Kim
Di-2-ethylhexyl phthalate (DEHP) are added to poly(vinyl chloride)(PVC) infusion tubes as a plasticizer to ensure tube flexibility. In addition to previously reported disadvantages of DEHP, released DEHP molec...
Ti and its alloys have been widely used as orthopedic and dental implants due to their outstanding mechanical properties and biocompatibility. However, long time is required to form bond between Ti implant and...
Authors: Soyoung Yang, Sujeong Lee, Indu Bajpai and Sukyoung Kim
Protein cage nanoparticles are promising nanoplatform candidates for efficient delivery systems of diagnostics and/or therapeutics because of their uniform size and structure as well as high biocompatibility a...
Authors: Hyojin Moon, Jisu Lee, Hansol Kim, Somin Heo, Junseon Min and Sebyung Kang
Photodynamic therapy (PDT) is an emerging treatment modality that involves the combined action of photosensitizers (PSs) and light for treatment of solid tumor and other diseases. Although this therapeutic met...
For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone filler...
Authors: June-Ho Byun, Han A Reum Lee, Tae Ho Kim, Jin Ho Lee and Se Heang Oh
The research trends on stent for blood arteries are reviewed by bibliometric analysis using 7,790 journal articles published from 1986 to 2013 of the Web of Science database. The bibliometric indicators are ap...
Authors: Sejung Ahn, Jung-Suk Sung, Brad Choi, Hackjoo Kim and Yong Kiel Sung
Immobilizing bioactive molecules and osteoconductive apatite on titanium implants have investigated direct ossification. In this study, hydroxycholesterol (HC) was immobilized with apatite on titanium through ...
Authors: Cen Chen, Hyeong Cheol Yang and In-Seop Lee
Membrane covered drug eluting stents (DES) were prepared to prevent tumor ingrowth and to control drug release. Polyurethane (PU) is commonly used for DES coating material because of high tensile strength. The...
M13 bacteriophages can be readily fabricated as nanofibers due to non-toxic bacterial virus with a nanofiber-like shape. In the present study, we prepared hybrid nanofiber matrices composed of poly(lactic-co-glyc...
Authors: Yong Cheol Shin, Jong Ho Lee, Linhua Jin, Min Jeong Kim, Jin-Woo Oh, Tai Wan Kim and Dong-Wook Han
Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical app...
Authors: Huan Fan, Soung Min Kim, Yun Ju Cho, Mi Young Eo, Suk Keun Lee and Kyung Mi Woo
The aim of this study was to evaluate the biocompatibility and resorption pattern in three-layer poly (lactide-co-glycolide) (PLGA) membrane according to the concentrations of hyaluronic acid (HA) hydrogel in ...
Authors: Hoon You, Eun-Ung Lee, You-Kyoung Kim, Bum-Chul Kim, Jin-Young Park, Hyun-Chang Lim, Jung-Seok Lee, InSup Noh, Ui-Won Jung and Seong-Ho Choi
Scaffolds are one of the three most important elements constituting the basic concept of regenerative medicine, and are included in the core technology of regenerative medicine along with stem cells and tissue...
Authors: Seou Lee, Taehoon Kwon, Eun Kyung Chung and Joon Woo Lee
Cell migration is an essential activity of the cells in various biological phenomena. The evidence that electrotaxis plays important roles in many physiological phenomena is accumulating. In electrotaxis, cell...
Authors: Min Sung Kim, Mi Hee Lee, Byeong-Ju Kwon, Hyok Jin Seo, Min-Ah Koo, Kyung Eun You, Dohyun Kim and Jong-Chul Park
