Fig. 1
From: Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy
Schematic illustration showing targeting of ‘exposed’ CLDN4 by CPE17-conjugated liposomes for pancreatic cancer chemotherapy. Dox-loaded, CPE17-conjugated liposomes (D@C-LPs) showed extensive accumulation in targeted pancreatic tumor tissues through the EPR effect and targeting of superficially exposed CLDN4, made accessible by disruption of tight junctions. In contrast, accumulation of D@C-LPs in the normal pancreas was significantly reduced because ‘hidden’ CLDN4 in these tissues is sequestered in tight junctions, hindering access to CPE17