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Fig. 1 | Biomaterials Research

Fig. 1

From: Inhibition of DAMP actions in the tumoral microenvironment using lactoferrin-glycyrrhizin conjugate for glioblastoma therapy

Fig. 1

Schematic illustration and synthetic procedure for Lf-GL. a In the tumor microenvironment, HMGB1 secreted from GBM cells binds to RAGE and is involved in cancer development and angiogenesis. Lf-GL delivered to the tumor microenvironment through interactions with LfR overexpressed in BBB and GBM cells inhibits its activity with high binding affinity to HMGB1. Thereby, Lf-GL can inhibit GBM-mediated angiogenesis activated by HMGB1 while limiting tumor development. b Synthetic procedure of Lf-GL conjugation. NaIO4 refers to sodium periodate; NaBH3CN refers to cyanoborohydride; text under arrow refers to synthesis conditions. The illustration was created with BioRender.com

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Biomaterials Research

ISSN: 2055-7124

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