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Fig. 7 | Biomaterials Research

Fig. 7

From: Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Fig. 7

Validation of Ca2+ influx-NFATc1-ATF3 signaling inside the tumors. (A) Immunofluorescence staining and (B) quantitative analysis of Fluo-4 AM in the tumors after different treatments. The bar is 100 μm. Data are represented as mean ± SD, n = 5. **P < 0.01. (C) Immunofluorescence staining and (D) quantitative analysis of NFATc1 in the tumors after different treatments. The bar is 400 μm (upper) and 40 μm (lower). Data are represented as mean ± SD, n = 5. *P < 0.05; ***P < 0.001 vs. Control. (E) Immunofluorescence staining of ATF3 in the tumors after different treatments. The bar is 50 μm

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