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Fig. 2 | Biomaterials Research

Fig. 2

From: Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Fig. 2

In vitro penetration and drug diffusion. (A) Force-distance curve of different CBD-SD@DMNs. (B) Images of porcine skins treated with different formulations and the H&E-stained sections. The bars are 2.5 mm (upper) and 200 μm (lower), respectively. (C) Dynamic transdermal flux of various formulations within 8 h. Data are represented as mean ± SD, n = 6. **P < 0.01; ##P < 0.01 vs. the corresponding formulation at pH 7.4. (D) Skin retention of CBD after 8 h of treatments with different formulations. Data are represented as mean ± SD, n = 6. **P < 0.01. (E) Fluorescence images of various C6-labeled formulations-treated skins. The blue is DAPI and the green is the C6 signal. The bar is 200 μm (upper) and 450 μm (lower). (F) Skin retention of CBD after 8 h of treatments with the two effervescent DMNs at different pH values. Data are represented as mean ± SD, n = 6. *P < 0.05; **P < 0.01

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