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Fig. 1 | Biomaterials Research

Fig. 1

From: Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Fig. 1

Preparation and characterizations of Ef/CBD-SD@DMNs. (A) Pictures of the patches (bar, 1 cm). The right part is the corresponding optical micrograph (bar, 500 μm). (B) SEM images and EDS analysis of CBD-SD@DMNs (upper) and Ef/CBD-SD@DMNs (lower). The bar is 250 μm. (C) XRD spectrum of CBD-associated formulations. (D) Cumulative dissolution of CBD from Ef/CBD-SD@DMNs at different pH values. Data are represented as mean ± SD, n = 6. **P < 0.01. (E) CO2 bubbles production and dissolution of the arrays in different pH environments within 150 s. The bar is 200 μm

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