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Fig. 1 | Biomaterials Research

Fig. 1

From: Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fibroblasts

Fig. 1

The scheme for the copper-induced injectable hydrogel and its pathway in enhanced cancer immunotherapy via amplified ICD and depletion of CAFs. The synergistic therapy of formed hydrogel amplified ICD to mature the DC and increase the recruitment of CD8 T cells. Furthermore, the NO released from formed hydrogel could interfere with CAFs to decrease the ECM and differentiation M2 macrophages to reverse immunosuppressive TME. With the antibody of PD-1, the self-assembled hydrogel could enhance the immunotherapy with enhanced ICD and depletion of CAFs

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Biomaterials Research

ISSN: 2055-7124

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