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Table 1 Comparison of bulk imprinting and surface imprinting

From: Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications

Method

Bulk imprinting

Surface imprinting

Reference

Fabrication accessibility

Easy

Complicated

[36, 72]

Template conformational maintence

Usually hard

Easy

[46]

Template utilization efficiency

Usually low

Usually high

[38, 73]

Template removal

Hard

Complete removal

[74, 75]

Rebinding capacity

Low

High

[36, 76]

Recognition site accessibility

Low

Easy

[35, 39]