Fig. 9

A Schematic illustration of drug delivery route of RNase A@biodegradable silica nanoparticles (BS-NPs) through redox-triggered biodegradation. B Time-dependent variation of fluorescence intensity at tumor sites of HepG2 tumor-bearing mice. C Ex vivo fluorescence imaging of tumor and other organs collected from mice in the sialic acid (SA)-imprinted molecularly imprinted polymer (MIP) and nonimprinted (NIP) group after 72 h. D Relative tumor volume growth curves of the mice during the 15 d of treatment. E Photograph of the dissected tumors in each treated group. F Schematic representation of targeted fluorescent imaging and glutathione (GSH)/pH-responsive drug delivery route of FZIF-8/DOX-MIPs. G Confocal microscopy images of MCF-7 cancer cells after coculture with FZIF-8/DOX-MIPs for 1 h. H Fluorescence images of MCF-7 tumor-bearing mice with at different times after intraperitoneal injection of MIPs and NIPs. I Relative tumor volume and (J) representative photographs of excised tumors in different groups after 20 d of treatment. A, B, C, D, E Reproduced with permission from [93], published by American Chemical Society 2021. F, G, H, I, J Reproduced with permission from [131], published by American Chemical Society 2020