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Fig. 5 | Biomaterials Research

Fig. 5

From: Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications

Fig. 5

A Reaction mechanism of polymerization of dopamine. B Preparation of mir-21 imprinted polymer coated silica nanoparticles. C miR-21 relative expression in the U-87 MG cell lysate using, Trizol reagent, NIP and MIP. D Synthesis of MIP-quantum dots (QDs), and their interactions with double-stranded DNA (dsDNA). E Fluorescence spectra of MG (7.0 μM) in the presence of MIP-QDs (0.1 mg/mL) upon addition of dsDNA in buffer (pH 7.4). Inset: Change in fluorescence emission intensity of MG at 660 nm depending on dsDNA concentration. F RTP spectra of MIP-QDs in the presence of MG as a function of dsDNA concentrations; a) 0 ~ i) 9.6 μg/mL. Inset: Change in RTP intensity of MIP-QDs at 594 nm with dsDNA addition. G Schematic illustration of the MIPs-based E-DNA biosensing. Inset of (i) and (ii) display the preparation of SiO2@Ag/DNA and homogeneous DNA hybridization. H DPV responses of AuNPs-GO/GCE, NIPs/AuNPs-GO/GCE, MAA/AuNPs-GO/GCE, Nafion/AuNPs-GO/GCE, and MIPs/AuNPs-GO/GCE in 0.1 mM PBS (pH 7.4) after incubation with SiO2@Ag/dsDNA/RhoB for 35 min. I calibration curve used for detection of T-DNA from 10 fM to 100 nM. A, B, C Reproduced with permission from [101], published by Elsevier 2020. D, E, F Reproduced with permission from [102], published by John Wiley and Sons 2016. G, H, I Reproduced with permission from [103], published by Elsevier 2018

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