Table 5 Cellulose-based hydrogel
System | Substance | Mechanism | Signal pathway | Cell line | Animal | Wound size | characteristic | Ref. |
|---|---|---|---|---|---|---|---|---|
Carbomer 940, CMC | Periplaneta americana herbal residue | Wound closure, collagen deposition, angiogenesis (+) | TNF-α, IL-10, VEGF, the transition of macrophages from M1 to M2(+) | 3T3 fibroblast | STZ-induced diabetic rat model | One, 2 cm | Porous structure, good rheological property, swelling capability, biocompatibility | [206] |
Oxidized CMC | Polyethyleneimine and tobramycin | Granulation tissue, collagen deposition, angiogenesis (+) | Arg-1(+); F4/80, iNOS, TNF-α(-) , | NCTC clone 929 cells (L cells, L-929), HUVECs | STZ-induced diabetic rat model | One, 1 cm | Anti-inflammation, anti-infection, injectable, self-healing, biocompatible properties, pH-sensitive | [207] |
silk fibroin, CMC | MnO2 nanosheets | ECM integration, angiogenesis(+); inflammatory level (-) | NA | L929 cells | STZ-induced diabetic rat model | One, 1 cm | Injectable, biocompatible, ROS scavenging, sustained O2 generation | [205] |
Hydroxypropyl methylcellulose | Val loaded solid lipid nanoparticles | NA | COX-2, NF-κB, NO, TGF-β, VEGF, MMPs (+) | NA | STZ-induced diabetic rat model | A layer of the skin in 3x5 mm thickness wound on the foot’s dorsal surface | Anti-infection | [208] |