Fig. 7

A Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel (HA-PF) promotes diabetic wound healing. a SEM image of cross-linked HA with different molecular weights (Mw). b The healing rate (%) of mice with full-thickness wounds following treatment with crosslinked hydrogels (Mw ¼ 1,800–2,200 kDa) at concentrations of 4%, 8% and 12%. c The mRNA expression of cytokines in the wound following different treatments. d The mRNA expression of CD31, VEGF, α-SMA and type I collagen in the wound following different treatments. B HA-based hydrogel grafted with methacrylic anhydride and N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butanamide (NB) groups to encapsulate lyophilized amnion-derived conditioned medium (AM-CM). a Schematic illustration of the preparation process of the HNM hydrogel encapsulated with freeze-dried AM-CM. b Photographs of the in situ formation of the HNM-M hydrogel (200 μL, 2 wt%) on pork skin after light irradiation. No detachment or breakage between the pork skin and hydrogel was observed after being stretched or twisted. c SEM image of tissue section of in situ formed hydrogel in pork skin. d Scheme of the lap-shear adhesion test to determine the hydrogel-tissue binding strength and quantification of the adhesive strength of the HNM-M hydrogel. Reproduced from [156, 157] with permission from Elsevier Copyright 2021, 2022