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Fig. 7 | Biomaterials Research

Fig. 7

From: Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Fig. 7

Oxylipin profiles in the sepsis heart were improved by UTMD-mediated RORα overexpression, not by a mild dose of melatonin supplementation alone. (A) Experimental scheme for oxylipin analysis. (B) Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) showing cardiac oxylipin profiles of sepsis and control group, sepsis and sepsis with melatonin treatment, and sepsis and sepsis with RORα delivery and melatonin treatment. (C) Heat map showing cardiac levels of overall oxylipins across four groups: control, sepsis, sepsis with melatonin treatment, sepsis with RORα delivery, and melatonin treatment. Downregulation and up-regulation are presented in blue and red, respectively. (D) Oxidized products derived from linoleic acid (LA). (E) Oxidized metabolites of arachidonic acid (ARA)

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Biomaterials Research

ISSN: 2055-7124

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