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Fig. 1 | Biomaterials Research

Fig. 1

From: Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding

Fig. 1

HUVECs and MSCs form interconnected MVNs within the microfluidic device. (A) Device dimensions of the three-channel microfluidic device. (B) Photograph and schematic of cell seeding into the three-channel microfluidic device. HUVECs and MSCs are seeded in a fibrinogen solution into the center channel via the cell inlet port. The co-supplemented thrombin induces fibrin polymerization within 20 min. Over the next two days, seeded cells re-arrange into interconnected MVNs within the fibrin hydrogel. (C) Representative phase contrast micrographs of seeded HUVECs and MSCs forming MVNs in microfluidic devices within 2 days. Scale bar = 400 μm

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Biomaterials Research

ISSN: 2055-7124

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