Fig. 1

Schematic illustration of MPCZ nanoplatforms as ROS generation and Mn²⁺ release for enhanced STING signaling pathway activation and amplified innate immunotherapy. After MPCZ NPs reaches the tumor area, the PTT effect of PDA can promote the decomposition of NH₄HCO₃, the collapse of PDA and the exposure of MnO₂ under 808 nm laser irradiation. Moreover, in tumor cells, under the action of high concentration GSH, the generation of Mn²⁺ and the release of ZPP will be triggered, and more ROS will be generated in an open source and reduce expenditure strategy. The generation of ROS and Mn²⁺ can jointly promote the activation of cGAS-STING signaling pathway and enhance the anti-tumor immune response