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Fig. 5 | Biomaterials Research

Fig. 5

From: Regenerated silk fibroin based on small aperture scaffolds and marginal sealing hydrogel for osteochondral defect repair

Fig. 5

Osteochondral engineering using the all-RSF-derived composite in vivo: a Procedures for the hybrid scaffolds and RSF solution application; b Schematic of each group are as follows: Group A: All chondrocytes; Group B: All BMSCs; Group C: Mixed cells; Group D: Group C + β-TCP; Group E: Group D + 14 wt% RSF solution; c Surgical procedures for the use of scaffolds combined with RSF solution in the osteochondral repair; d, e Gross images and micro-CT images; f BV/TV (%) values of micro-CT bone remodeling were quantitatively measured; g ICRS macroscopic repair scores were quantified; h H&E staining, Saf-O/Fast Green staining, COL II IHC, and Masson–Goldner staining (the black arrow indicates the junction between the material and the tissue surrounding the defect) of repaired cartilage subchondral bone at four months post-surgery; i Relative expression analysis of COL II IHC with ImageJ

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