Fig. 9

Schematic diagram of PEG based biomaterials for tumor immunotherapy. A Schematic illustration of size‐transformable supramolecular nanoprodrug (PDNP). (a) Structure of PDNPs and the mechanism of pH cascade‐responsive conversion and drug release. (b) Schematic diagram of anti-tumor effect of PDNP. B Antitumor efficacy of PDNPs. (a) Schematic illustration of PDNPs for enhanced intratumor penetration in CT26 MCSs. (b) Plasma concentration of DOX versus time of PDNPs upon administration of PDNPs and free DOX in S.D. rats. (c) The circulating half‐life (t 1/2) of PDNPs and free DOX. (d) In vivo NIR imaging of free DiR and PDNPs@DiR in CT26‐bearing mice. (e) CLSM images of the distribution and penetration of PDNPs in the slices of CT26 tumor tissue. (f) Quantitative analysis of the excised tumors and organs at 48 h postinjection. (g) The immunofluorescence staining of excised tumor tissues after treatments. (Reproduced with permission from [101] Copyright © 2022, Advanced Science)