Fig. 8

RNA-seq assessments of diabetic wounds at day 14 after treatment with DSeP@PB + RL. (A) Volcano plot of significant gene expression changes in the DSeP@PB + RL/control comparison. (B) Genes involved in immune regulation as measured by GO classification analysis and a list of the top 30 upregulated genes and corresponding log2Fc (log2-fold change). (C) KEGG pathway enrichment analysis of the DSeP@PB + RL/control comparison. (D) GO classification analysis of the DSeP@PB + RL/control comparison. (E) Gene expression involved in BP, CC and MF was quantified. (F) Gene expression analysis of the inflammatory response, angiogenesis and positive regulation of cell proliferation in diabetic wounds, with data normalized to the control group (without treatment). n = 3 mice per treatment