Fig. 7
From: Advanced pathophysiology mimicking lung models for accelerated drug discovery
Comparison between developed disease lung model and commercial MucilAir™-HF derived from COPD donors. A IF staining (ZO-1: red, DAPI: blue); Scale bar: 50 µm, SEM images, and histological cross-sections (H&E staining) and IF staining displaying essential epithelial features, including acetylated α-tubulin (green) – marker for ciliated cells and MUC5B (red) – marker for goblet cells for the static culture and dynamic culture; Objective 40x, scale bar: 50 µm. B the electrical resistance value at the end of the culture (Day 25). Error bars denote standard deviation, n = 3 for CNBio NHBE-NHLF and n = 2 for MucilAir™-HF derived from COPD donors