Fig. 9
From: Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery
A schematic illustration of the synthetical route of MTX@AuNCs-CS-AS1411, and the proposed blood circulation and intracellular uptake and drug release. The actively targeted nanoparticles can be released in a controlled manner, achieving enhanced targeting efficacy by active targeting to individual tumor cell and deep penetration within the tumor tissue. Reproduced with permission from Guo et al. [109]. Copyright Elsevier (2018)