Fig. 5

Hieratical clustering functional annotation of proteins with p-values less than 0.05 in one-way ANOVA tests. A A heatmap of 164 proteins by Euclidean distances with complete linkage has three protein clusters. B Functional GO network displaying groupings of biological process terms enriched in cluster 1 (magenta), cluster 2 (apricot), and cluster 3 (blue). Row labels consist of the top 100 proteins in Vesiclepedia (red bar), brain-elevated proteins in the Human Protein Atlas (green bar), and proteins annotated in Synaptic Gene Ontologies (SYNGO; yellow bar). C A truncated heatmap of 21 proteins related to neuronal mechanisms. D Association between the proteins (green circle: brain-elevated proteins, yellow: SYNGO, red: both) and disease (magenta hexagon) or functional annotation terms (blue square).