Fig. 8

Combination of RD@MBs with αPD-L1 chemoimmunotherapy activated systematic antitumor response. a Schematic illustration of the experiment design for antitumor immune responses. b The proportions of CTLs (CD3⁺CD4⁻CD8⁺) in spleens. c FCM results of CTLs (CD3⁺CD4⁻CD8⁺) in spleen. d FCM results of CTLs (CD3⁺CD4⁻CD8⁺) in tumor. e The proportions of Tregs (CD3⁺CD4⁺Foxp3⁺) in spleens. f-g The proportions of CTLs (CD3⁺CD4⁻CD8⁺) and Tregs (CD3⁺CD4⁺Foxp3⁺) in tumors. h IFN-γ levels in serum. Data are expressed as mean ± SD (n = 3). Statistical significances were calculated via Student’s t test, *p < 0.05, **p < 0.01 and ***p < 0.001