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Fig. 7 | Biomaterials Research

Fig. 7

From: Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment

Fig. 7

In vivo polarization of TAMs. a Schematic illustration of the experiment design for in vivo FCM. b-c FCM and corresponding quantification of MDSCs (CD11b+Gr-1+) in spleens. d-e The proportions of M1-TAMs (CD11b+F4/80+CD86+) and M2-TAMs (CD11b+F4/80+CD206+) in spleens. f FCM results of M1-TAMs (CD11b+F4/80+CD86+) and M2-TAMs (CD11b+F4/80+CD206+) in spleens. g FCM results of M1-TAMs (CD11b+F4/80+CD86+) and M2-TAMs (CD11b+F4/80+CD206+) in tumors. h-i The proportions of M1-TAMs (CD11b+F4/80+CD86+) and M2-TAMs (CD11b+F4/80+CD206+) in tumors. j-k Quantification of IL-10 and IL-12 levels in serum. Data are expressed as mean ± SD (n = 3). Statistical significances were calculated via Student’s t test, *p < 0.05, **p < 0.01 and ***p < 0.001

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