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Fig. 4 | Biomaterials Research

Fig. 4

From: Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

Fig. 4

Common post-decellularization modifications to address the immunogenicity of dECM scaffolds. A Selective antigen removal techniques rely on enzymatic treatment to specifically remove antigens (i.e., α-gal, Neu5Gc, and Sda epitopes). B Crosslinking may reduce the immunogenicity of dECM by masking exposed antigenic sites. C Solubilization removes various protein antigens (hydrophobic and hydrophilic antigens) according to their common physiochemical properties. D Terminal sterilization eliminates pathogen-related immunogenicity of viruses and bacteria in the dECM scaffolds

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Biomaterials Research

ISSN: 2055-7124

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