Fig. 8

Biocompatibility evaluation of the hydrogels for treating PD rats. A In vivo immunofluorescent images of CD86 positive (CD86+) M1 macrophages (red) and CD163 positive (CD163+) M2 macrophages (green) for the explanted tissue after implantation in the brain for 14 days. Quantification for (B) the fluorescent intensity of M1 and M2 macrophages and (C) the ratios of M2/M1 in vivo. *p < 0.05, **p < 0.01, and ****p < 0.0001 between the indicated groups