Fig. 6

Behavior tests of Parkinson’s disease (PD) rats treated by hydrogels. A Schematic illustration of the PD rat model. 6-hydroxydopamine (6-OHDA) as a neurotoxin was utilized to induce PD through injection into the brains of rats. After confirmation of PD induction, the hydrogels were further injected into the lesion regions for 14 days, and the efficacy of treatment was evaluated through behavior tests, electrophysiological tests, and immunofluorescent analyses. B, C Quantitative assessment for the functional recovery of different condition treated PD rats (injected by saline, CO hydrogel, COA2 hydrogel, or COA2 hydrogel loaded with curcumin) as compared to the untreated PD rats (0 day), based on the left-side circling speeds (B) and the impaired forelimb contact proportion (C). **p < 0.01, ***p < 0.001, and ****p < 0.0001 between the indicated groups