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Fig. 5 | Biomaterials Research

Fig. 5

From: Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Fig. 5

In vitro antioxidation and anti-inflammatory evaluations of the hydrogels. A Cell viability tests for either healthy or inflamed NSCs. Scatter plots showed changes in propidium iodide (PI) and Vitabright-48 (VB-48) staining in response to the cell treatment with encapsulation by the CO hydrogel and COA2 hydrogel compared to the single cells (mock). B Summary for the distribution of inflamed NSC status after the treatment of CO hydrogel or COA2 hydrogel compared to the single inflamed cells (mock). C Quantification for the rescue rate and dead rate of the inflamed NSCs after the treatment of the CO hydrogel or COA2 hydrogel for 12 h. D Gene expression of the J774A.1 macrophages analyzed by RT-PCR after contacting the CO hydrogel or COA2 hydrogel for 6 h compared to macrophages cultured on the tissue-culture polystyrene plate (TCPS) in vitro. The expression levels were normalized to that of β-actin and represented by the relative ratios of gene expression. *p < 0.05 and **p < 0.01 between the indicated groups

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