Fig. 4
From: Reprogramming the tumor microenvironment with biotechnology
Targeting CD47 and SIRPα with nanoparticles. a 2C8 inhibits tumor growth in xenotransplantation models. Mice were treated with two different doses of 2C8 or Phosphate-buffered saline. The tumor volume of tumors per group is depicted over time. (Reproduced with permission from [53] Copyright 2020, Frontiers in Oncology). b Schematic showing repolarization of M2 to M1 and promoting phagocytosis by blocking the signal in tumor cells by IMD@Hf-DBP/αCD47 and X-ray radiation (Reproduced with permission from [54] Copyright 2020, American Chemical Society)