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Fig. 1 | Biomaterials Research

Fig. 1

From: Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3

Fig. 1

Synthesis and biomedical application of verapamil-loaded CLCMP (Vera@CLCMP) hydrogel patches. A Schematic illustration of Vera@CLCMP hydrogel patch attached to the mouse dorsal skin. Controlled release of the loaded verapamil in the superporous hydrogel system permeates to the stratum corneum or even deep dermis, thus reversing diet-induced obesity and insulin resistance. Vera@CLCMP patches attenuate obesity-induced metabolic dysregulation by improving autophagic clearance through regulation of CaMKII activity and NLRP3-inflammasome activation in hepatocytes. B Chemical structures schemes of Vera@CLCMP hydrogel patches

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Biomaterials Research

ISSN: 2055-7124

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