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Fig. 7 | Biomaterials Research

Fig. 7

From: A simple method to isolate structurally and chemically intact brain vascular basement membrane for neural regeneration following traumatic brain injury

Fig. 7

Glial cells and neural progenitor cells populated lesion sites 10 and 20 days after brain-VBM placement. Ten days after surgery, some nestin-expressing cells (NPCs) were identified at the perimeter of the brain-VBM, and nestin expression further increased at postoperative day 20. At 10 days, many astrocytes surrounding the lesion site were activated, but few astrocytes had migrated into the brain-VBM; at day 20, although more astrocytes were activated, only a few GFAP-expressing cells were present in the lesion site. Radial glial progenitor cells (RGPs) are NPCs. At the early postoperative stage, we found that RGPs were present around the lesion site, but they were less at day 20. Red dashed lines are the boundary between lesion site and host tissue. Triangles (red asterisks) represent a completely decomposed brain-VBM. Scale bars: 100 μm. Statistical significance was set at P < 0.05; *P < 0.05

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