Fig. 6

Tissue restoration after brain-VBM repair. A Comparison of the overall view and H&E-stained lesion region at 2 months after surgery between the brain-VBM group and the PBS group. The green dashed box indicates the scope of the original lesion site. The repair status of the lesion cavity in the two groups (B, red arrows; A: anterior, P: posterior) at different time points and the quantitative comparison (C) showed that cavity restoration in the brain-VBM group was significantly better than that in the PBS group. D In terms of neurological functional recovery, modified neurological severity scores (mNSSs) in the brain-VBM group at 4, 6, and 8 weeks after surgery were significantly lower than those in the PBS group at the same time points. E shows cell invasion (DAPI in graft site) and immune reactivity (CD68 in graft site) in the lesion cavity region in the brain-VBM group at 3 days, 7 days, and 14 days after surgery. F Quantification analysis indicates that the inflammation response was significantly reduced at postoperative day 7 and completely disappeared at postoperative day 14. Statistical significance was set at P < 0.05; *P < 0.05, **P < 0.01, and # indicates nonsignificant