Fig. 3

Characteristics of brain-VBM components. A-D Comparisons of the proteins and DNA in the native brain tissue and in the brain-VBM. E-F show that brain-VBM contained more ECM-promoting factors, including laminin, fibronectin, and collagen, but very few inhibitory components such as chondroitin sulfate proteoglycan. In terms of active growth factors and adhesive molecules, compared with normal brain tissue, brain-VBM still had a considerable amount of vascular endothelial growth factor (G) and most known adhesive molecular factors (H), but nerve growth factor was almost undetectable (G). I shows 25 significantly differentially expressed proteins related to ECM and the ratio of their respective contents in brain-VBM to native brain. Statistical significance was set at P < 0.05; *P < 0.05, **P < 0.01