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Fig. 8 | Biomaterials Research

Fig. 8

From: Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Fig. 8

Anti-tumor evaluation on the bilateral 4T1 tumor model to examine the abscopal effect. (A) Schedules for the indicated treatment. p.t. means peritumoral. Tumor volume of the primary (B) and the distal (C) tumors of each group (n = 5). (D) Immunofluorescence staining of CD11 (red) and CD86 (green) in distal tumors. (E) Recruitment of TH1 (CD4+IFN-γ+ T), CTL (CD8+IFN-γ+ T) and Treg (CD4+Foxp3+ T) in distal tumors. (F) Populations of CD80+ cells gated on CD11c+ DC cells in distal tumors. Representative flow cytometry profiles and quantitation of effector memory T cells (CD3+CD8+CD44+CD62L−) in the (G) distal tumors and in the (H) spleen of 4T1-bearing mice. Results were expressed as mean ± SD (n = 3). (1) PBS; (2) Rg3@PPP; (3) DOX@PPP; (4) Rg3-PNPs + DOX@PPP; (5) αPD-L1@PPP; (6) (Rg3-PNPs + DOX + αPD-L1)@PPP. *p < 0.05, **p < 0.01 vs. PBS group

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Biomaterials Research

ISSN: 2055-7124

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