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Fig. 7 | Biomaterials Research

Fig. 7

From: Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Fig. 7

Combination of Rg3-PNPs+DOX with αPD-L1 activated T cells in mice bearing 4T1 tumor. (A) Immunofluorescent staining of CD8 and PD-L1 expression in tumors. (B) Flow cytometry analysis to show the level of TH1 (CD4+IFN-γ+ T), CTL (CD8+IFN-γ+ T) and Treg (CD4+Foxp3+ T) in tumor-draining lymph nodes. Error bars indicate SD (n = 3). 1. PBS; 2. Rg3@PPP; 3. DOX@PPP; 4. Rg3+DOX@PPP; 5. Rg3-PNPs+DOX@PPP; 6. αPD-L1 (i.v.); 7. Rg3-PNPs+DOX@PPP+αPD-L1 (i.v.). *p < 0.05, **p < 0.01 vs PBS group

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Biomaterials Research

ISSN: 2055-7124

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