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Fig. 6 | Biomaterials Research

Fig. 6

From: Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Fig. 6

Antitumor efficiency of Rg3-PNPs + DOX combined with αPD-L1 in the orthotopic breast tumor model. A Schedules for the indicated treatment. p.t. means peritumoral. i.v. means intravenous. B Survival and (C) Tumor volume of each group (n = 5). D In vivo bioluminescence imaging of the 4T1-LUC tumors in different groups. E H&E staining and immunohistochemical analysis of Ki-67, α-SMA, CCL2 in tumor tissue (n = 3). (1) PBS; (2) PPP; (3) Rg3@PPP; (4) DOX@PPP; (5) Rg3 + DOX@PPP; (6) Rg3-PNPs + DOX@PPP; (7) αPD-L1; (8) Rg3-PNPs + DOX@PPP plus αPD-L1. *p < 0.05, **p < 0.01 vs. the PBS group

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Biomaterials Research

ISSN: 2055-7124

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