Fig. 6

Changes in the membrane receptor of HGEs cultured on the chemical surfaces. A Interactions network between the adsorbed proteins and integrin (ITG) family; representative western blot images (B), RT-qPCR results (C) and immunofluorescence images (D) of the expression of ITG β1 of HGEs in four groups; E binding scores of the lowest energy binding conformations of each groups during molecular docking calculations of the FN/ITGα5β1-membrane complex; F the optimal binding conformation and the detailed hydrogen bonding interactions of the FN-ppAA/ITGα5β1-membrane complex (first row), FN-ppAC/ITGα5β1-membrane complex (second row) and FN-ppME/ITGα5β1-membrane complex (third row). Significant differences between two groups with a p < 0.05 are presented as follows: a) versus ppAA group, b) versus ppAC group, c) versus ppME group, and d) versus control group