Fig. 6

In vivo mapping of BACE1 in AD model (5XFAD) mice. A the fluorescent image at 2 h, 4 h, 8 h, 24 h after intravenous injection of 2.0 mg kg^–1 of HBAE into wild-type mice and AD-model mice in vivo. B the fluorescent image of ex vivo brain of wild-type mice and AD-model mice at 2 h, 4 h, 8 h, 24 h after intravenous injection of 2.0 mg kg^–1 of HBAE. C Fluorescence intensity of wild-type mice and AD-model mice in vivo at 2 h, 4 h, 8 h, 24 h after intravenous injection of 2.0 mg kg^–1 of HBAE (^***P < 0.001). D Fluorescence intensity of ex vivo brain of wild-type mice and AD-model mice (^****P < 0.001)