Fig. 2From: Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosisIllustration for the working principle of the designed NIR ratiometric fluorescent probe HBAE for the determination of BACE1 in neurons and mouse brain tissue slice. A the 3D docked conformation of the BACE1 and HBAE of the X-ray structure of BACE1. B the 2D docked conformation of the BACE1 and HBAE of the X-ray structure of BACE1 (PDB entry 5I3Y)Back to article page