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Fig. 8 | Biomaterials Research

Fig. 8

From: Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Fig. 8

SIRPα-v Exos regulate microglial polarization via the p38-STAT1 and PI3K-Akt-mTOR signaling pathways. A Western blot images showing the protein levels of phospho-/nonphospho- p38 MAPK and STAT1 in primary microglia. B Quantification analysis of the expression of phospho/nonphospho-p38 MAPK and STAT1 by Western blotting (n = 4/group). * P < 0.05, ** P < 0.01, vs. Sham group; # P < 0.05, ## P < 0.01 vs. Con group; ▲ P < 0.05, ▲▲ P < 0.01 vs. NC Exo group; ns, no significance. C Representative Western blot images showing the protein levels of phospho/nonphospho-PI3K, Akt, and mTOR in primary microglia. D Quantification analysis of the phosphorylation levels of PI3K, Akt, and mTOR by Western blot (n = 4/group). E Schematic illustration of the proposed mechanisms underlying the regulation of microglia by SIRPα variants. * P < 0.05, ** P < 0.01, vs. Sham group; # P < 0.05, ## P < 0.01 vs. Con group; + P < 0.05, +  + P < 0.01, vs. SIRPα-v Exo group; ▲ P < 0.05, ▲▲ P < 0.01 vs. Treg group; ns, no significance. All the data are presented as the mean ± SD

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