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Fig. 6 | Biomaterials Research

Fig. 6

From: Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Fig. 6

SIRPα-v Exos modulated the polarization of microglia/macrophages after ICH. A Representative immunofluorescence images of CD16/32 (red), CD206 (green), and Iba1 (silver) in the ipsilateral STR around the hematoma on the 3rd day post-ICH (scale bar = 100 μm). B Quantification analysis of CD16/32+ and Iba1+ cells in the ipsilateral STR around the hematoma on the 3rd day post-ICH. C Quantification analysis of CD206+ and Iba1+ cells in the ipsilateral STR around the hematoma on the 3rd day post-ICH. D The mRNA levels of CD16, CD32, CD86, and CD11b (biomarkers for M1 microglia) and CD206, IL-10, TGFβ, and YM1/2 (biomarkers for M2 microglia) detected by RT-qPCR on the 1st, 3rd, 7th days post-ICH (n = 6/group). E Schematic illustration of the experimental design (separate application of SIRPα-v Exos) in vitro. F The mRNA levels of CD11b, CD16, CD32, and CD86 detected by RT-qPCR after separate application of SIRPα-v Exos (n = 3/group). G The mRNA levels of CD206, TGFβ, IL-10, and YM1/2 detected by RT-qPCR after separate application of SIRPα-v Exos (n = 3/group). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Sham group; # P < 0.05, ## P < 0.01 vs. Con group; ▲ P < 0.05, ▲▲ P < 0.01 vs. NC Exo group; ns, no significance. All the data are presented as the mean ± SD

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